The increasing number of older people is resulting in an increased prevalence of age-related diseases. Research has shown that the ageing process itself is a potential point of intervention. Indeed, gene expression can be optimized for health in older ages through manipulation of transcription factor (TF) activity.
A recent manuscript by Guillermo Martínez Corrales and his colleague focused on the ever-growing number of TFs whose effects on ageing are evolutionarily conserved. These regulate a plethora of functions, including stress resistance, metabolism, and growth. They are engaged in complex interactions within and between different cell types, impacting the physiology of the entire organism. Since ageing is not programmed, the conservation of their effects on lifespan is most likely a reflection of the conservation of their functions in youth.
Find out more about longevity during our 2nd World Congress on Ageing & Longevity on December 2022, in Tokyo – Japan.